The School of Biological Sciences Spring 2023 Seminar Series presents Dr. Sahin Naqvi

Sahin Naqvi, Ph.D.
Postdoctoral Fellow
Chemical and Systems Biology
Stanford University
Title: Analog genomics: Transcriptional dosage effects in human variation and disease

Quantitative effects on gene expression levels (dosage) underlie much of the genotype-to-phenotype pathway. In this talk, I will introduce “analog genomics,” which seeks to combine quantitative experimental and computational tools to understand gene regulation in human variation and disease. I will first discuss genetic studies of variation in human face and brain shape that revealed a key role for transcription factors (TFs) acting in facial progenitor cells. I will then describe an experimental approach to precisely modulate TF dosage and its application in dissecting the role of the dosage-sensitive TF SOX9 in craniofacial variation and disease. Future work will build upon these findings to understand mechanisms dictating dosage sensitivity and robustness in transcriptional networks across diverse developmental contexts.

Event Details


  • Thursday, January 26, 2023
    11:00 am - 12:00 pm
Location: Roger A. and Helen B Krone Engineered Biosystems Building, 950 Atlantic Drive, Atlanta, GA 30032, Room 1005

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  • Dr. Sahin Naqvi