The American Society for Pharmacology and Experimental Therapeutics (ASPET) has announced that a 2022 Molecular Pharmacology Early Career Award will be presented to Dr. Matthew Torres, faculty member in the School of Biological Sciences, in recognition of his scholarly achievements as a junior investigator in the field of molecular pharmacology.
Dr. Torres is receiving this award in recognition of his innovative research that combines genetics, mass spectrometry, and cutting-edge bioinformatics to understand how post-translational modifications impact protein function and cell physiology, and also in recognition of his strong commitment to teaching, mentoring and service. Dr. Torres is currently an Associate Professor in the School. He received his PhD in biochemistry and completed his postdoctoral training at the University of North Carolina at Chapel Hill.
The primary focus of Dr. Torres’s lab is to combine yeast genetics, mass spectrometry (MS) and bioinformatics to understand how post-translational modifications (PTMs) impact protein structure, function and cell behavior. His group studies how PTMs regulate G protein signaling pathways, with a current emphasis on the G protein gamma subunit. His lab also developed SAPH-ire (“Systematic Analysis of PTM Hotspots”), a bioinformatics tool that employs machine learning to prioritize PTMs important for protein function and provide recommendations for experimental analysis. Dr. Torres has been a member of ASPET since 2017.
The award will be presented by the Division for Molecular Pharmacology at the ASPET Annual Meeting in Philadelphia on Monday, April 4, 2022 where Dr. Torres will deliver a lecture on his research titled "From m/z to Gαβγ: Accessing the Collective Wisdom in Proteomics to Reveal Posttranslational Governors of G protein Signaling".
The talk will focus on the development of protein bioinformatic and computational tools that revealed how Gγ subunits - through phosphorylation of their intrinsically disordered N-termini - can serve as governors of Gβγ signaling.
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