Role of the Chromobox Homologue Protein (CBX2) in Cellular Senescence and Maintenance of Chromosome Stability in Mammalian Cells

Rabindranath De La Fuente DVM., Ph.D.
Department of Physiology and Pharmacology
University of Georgia

Attend via BlueJeans

ABSTRACT
Cellular senescence is a major contributor to tissue dysfunction and age-related decline in organismal health.The molecular mechanisms regulating changes in the chromatin landscape during cellular senescence are not fully understood. However, accumulating evidence indicates that changes in chromatin structure and function induced by altered epigenetic profiles are important contributing factors to the onset of cellular aging and predispose a cell to chromosome instability in the form of aneuploidy, deletions and translocations.The chromobox homologue protein 2 (CBX2) is a critical component of the Polycomb Repressive Complex (PRC1). CBX2 is an important epigenetic reader involved in the regulation of cell proliferation and differentiation that is overexpressed in a wide range of human tumors.However, its cellular and molecular function(s) are only beginning to be unraveled.This seminar will presentongoing projects andrecent findingson the role of CBX2 in maintenance of chromosome stabilityas well as the potential mechanisms leading to the onset of premature senescence in CBX2 knockout mouse cells.

Host: Yuhong Fan, Ph.D.